Article
Sequence analysis of the long control region of human papillomavirus type 16 variants and functional consequences for P97 promoter activity
1 Aug 2000
Abstract excerpt
Genital human papillomaviruses (HPV) are considered to be one of the main risk factors for the development of cervical cancer. The P97 promoter at the E6-proximal end of the long control region (LCR) regulates the transcription of viral genes, especially the oncogenes E6 and E7. The LCR contains binding sites of several viral and cellular transcription factors, which either activate or repress the P97 promoter....
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