Sequence variation of human papillomavirus type 16 E7 in preinvasive and invasive cervical neoplasias.

doi:10.1007/BF01703438

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Article

Sequence variation of human papillomavirus type 16 E7 in preinvasive and invasive cervical neoplasias.

Virus genes - 1 Sept 1994

Fujinaga Y, Okazawa K, Nishikawa A, Yamakawa Y, Fukushima M, Kato I, Fujinaga K

Abstract excerpt

Variation in the nucleotide sequence of the HPV 16 E7 gene in preinvasive cervical intraepitherial neoplasia (CIN) and invasive cervical carcinoma specimens was analyzed. Direct DNA sequencing of PCR-amplified products with primers different from those used for PCR with 5'-end labeling generated distinct sequence ladders with a low background, even in specimens containing relatively low copy numbers of HPV. Of 14...

Topics

Amino Acid Sequence
Base Sequence
Carcinoma in Situ
Cloning, Molecular
Codon
DNA Primers
DNA, Viral
Female
Genes, Viral
Genes, ras
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Molecular Sequence Data

Oncogene Proteins, Viral

Papillomaviridae

Papillomavirus E7 Proteins

Polymerase Chain Reaction

Transformation, Genetic

Source

Open in PubMed

Identifiers

PMID: 7871765
DOI: 10.1007/BF01703438

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7871765-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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