Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HPV16 E7 Nucleotide Variants Found in Cancer-Free Subjects Affect E7 Protein Expression and Transformation

6 Oct 2022

Abstract excerpt

The human papillomavirus (HPV) type 16 E7 oncogene is critical to carcinogenesis and highly conserved. Previous studies identified a preponderance of non-synonymous E7 variants amongst HPV16-positive cancer-free controls compared to those with cervical cancer. To investigate the function of E7 variants, we constructed full-length HPV16 E7 genes and tested variants at positions H9R, D21N, N29S, E33K, T56I, D62N,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Cervical Cancer and HPV Research
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36230818
DOI: 10.3390/cancers14194895

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HPV16 E7 Nucleotide Variants Found in Cancer-Free Subjects Affect E7 Protein Expression and TransformationPMID 36230818Read ↗

HPV16 E7 Nucleotide Variants Found in Cancer-Free Subjects Affect E7 Protein Expression and TransformationSemantic proximity Read ↗

HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis.Semantic proximity Read ↗

HPV16 E7 oncogene expression in normal human epithelial cells causes molecular changes indicative of an epithelial to mesenchymal transitionSemantic proximity Read ↗

Characterization of patient-derived HPV16 E6 and E7 variant alleles.Semantic proximity Read ↗

Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control.Semantic proximity Read ↗

The human papillomavirus 16 European-T350G E6 variant can immortalize but not transform keratinocytes in the absence of E7.Semantic proximity Read ↗

Enhanced oncogenicity of Asian-American human papillomavirus 16 is associated with impaired E2 repression of E6/E7 oncogene transcriptionSemantic proximity Read ↗

Sequence analysis of the long control region of human papillomavirus type 16 variants and functional consequences for P97 promoter activitySemantic proximity Read ↗

Phylogenetic and functional analysis of sequence variation of human papillomavirus type 31 E6 and E7 oncoproteins.Semantic proximity Read ↗

Sequence variation of human papillomavirus type 16 E7 in preinvasive and invasive cervical neoplasias.Semantic proximity Read ↗

Major Sequence Variants in E7 Gene of Human Papillomavirus Type 16 from Cervical Cancerous and Noncancerous Lesions of Korean WomenSemantic proximity Read ↗

The E8 Domain Confers a Novel Long-Distance Transcriptional Repression Activity on the E8^E2C Protein of High-Risk Human Papillomavirus Type 31Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.