Article

Enhancing Hepatic MBOAT7 Expression Does Not Improve Nonalcoholic Steatohepatitis in Mice

2022-03-24

Abstract excerpt

<h4>Background & Aims</h4> Genetic analyses of human NASH have revealed polymorphisms near the membrane bound O-acyl transferase domain containing 7 ( MBOAT7 ) gene associated with worsened liver injury. NAFLD/NASH also appears to decrease MBOAT7 expression or activity independent of these polymorphisms. Thus, we hypothesized that enhancing MBOAT7 function in NASH would improve pathology. <h4>Approach & Results...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ebe5ffeb-381c-58cc-96bd-4a52e1708bb2
DOI: 10.1101/2022.03.24.485677

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Enhancing Hepatic MBOAT7 Expression Does Not Improve Nonalcoholic Steatohepatitis in MiceDOI 10.1101/2022.03.24.485677Read

Membrane Bound O-Acyltransferase 7 (MBOAT7)-Driven Lysophosphatidylinositol (LPI) Acylation in Adipocytes Contributes to Systemic Glucose HomeostasisSemantic proximity Read

Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver InjurySemantic proximity Read

Loss of hepatic Mboat7 leads to liver fibrosis.Semantic proximity Read

MBOAT7 in liver and extrahepatic diseases.Semantic proximity Read

Low MBOAT7 expression, a genetic risk for MASH, promotes a profibrotic pathway involving hepatocyte TAZ upregulation.Semantic proximity Read

Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitisSemantic proximity Read

MBOAT7 down-regulation by genetic and environmental factors predisposes to MAFLD.Semantic proximity Read

Hepatic loss of AATF attenuates MASH by suppressing AKT–mTORC1 signaling and reprogramming lipid metabolismSemantic proximity Read

Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver diseaseSemantic proximity Read

Hepatocyte-Targeted siTAZ Therapy Lowers Liver Fibrosis in NASH Diet-Fed Chimeric Mice with Hepatocyte-Humanized LiversSemantic proximity Read

Catechin-Rich Green Tea Extract and the Loss-of-TLR4 Signaling Differentially Alter the Hepatic Metabolome in Mice with Nonalcoholic Steatohepatitis.Semantic proximity Read

The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humansSemantic proximity Read