Low MBOAT7 expression, a genetic risk for MASH, promotes a profibrotic pathway involving hepatocyte TAZ upregulation.

doi:10.1097/HEP.0000000000000933

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Article

Low MBOAT7 expression, a genetic risk for MASH, promotes a profibrotic pathway involving hepatocyte TAZ upregulation.

Hepatology (Baltimore, Md.) - 1 Feb 2025

Moore Mary P, Wang Xiaobo, Kennelly John Paul, Shi Hongxue, Ishino Yuki, Kano Kuniyuki, Aoki Junken, Cherubini Alessandro, Ronzoni Luisa, Guo Xiuqing, Chalasani Naga P, Khalid Shareef, Saleheen Danish, Mitsche Matthew A, Rotter Jerome I, Yates Katherine P, Valenti Luca, Kono Nozomu, Tontonoz Peter, Tabas Ira

Abstract excerpt

BACKGROUND AND AIMS: The common genetic variant rs641738 C>T is a risk factor for metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis (MASH), including liver fibrosis, and is associated with decreased expression of the phospholipid-remodeling enzyme MBOAT7 (LPIAT1). However, whether restoring MBOAT7 expression in established metabolic...

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Identifiers

PMID: 38776184
DOI: 10.1097/HEP.0000000000000933
PMCID: PMC11822724

Genes

MBOAT7
IHH
WWTR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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