Article

Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease

2023-03-21

Abstract excerpt

<h4>ABSTRACT</h4> Somatic mutations in non-malignant tissues accumulate with age and insult, but whether these mutations are adaptive on the cellular or organismal levels is unclear. To interrogate mutations found in human metabolic disease, we performed lineage tracing in mice harboring somatic mosaicism subjected to non-alcoholic steatohepatitis (NASH). Proof-of-concept studies with mosaic loss of Mboat7 , a m...

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Literature Corpus work: b75d99f5-fe02-558e-92ab-c204bb5188c9
DOI: 10.1101/2023.03.20.533505

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