Article

Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury

2023-09-27

Abstract excerpt

Several recent genome-wide association studies (GWAS) have identified single nucleotide polymorphism (SNPs) near the gene encoding membrane-bound O -acyltransferase 7 ( MBOAT7 ) that is associated with advanced liver diseases. In fact, a common MBOAT7 variant (rs641738), which is associated with reduced MBOAT7 expression, confers increased susceptibility to non-alcoholic fatty liver disease (NAFLD), alcohol-as...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9fab2ae6-e7fe-58fa-a8b6-ed18d220d814
DOI: 10.1101/2023.09.26.559533

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver InjuryDOI 10.1101/2023.09.26.559533Read

Membrane Bound O-Acyltransferase 7 (MBOAT7)-Driven Lysophosphatidylinositol (LPI) Acylation in Adipocytes Contributes to Systemic Glucose HomeostasisSemantic proximity Read

MBOAT7 in liver and extrahepatic diseases.Semantic proximity Read

Loss of hepatic Mboat7 leads to liver fibrosis.Semantic proximity Read

MBOAT7 down-regulation by genetic and environmental factors predisposes to MAFLD.Semantic proximity Read

Enhancing Hepatic MBOAT7 Expression Does Not Improve Nonalcoholic Steatohepatitis in MiceSemantic proximity Read

The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humansSemantic proximity Read

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent.Semantic proximity Read

The Lipid Hydrolase ABHD6 is a Therapeutic Target in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)-Related Hepatocellular CarcinomaSemantic proximity Read

Low MBOAT7 expression, a genetic risk for MASH, promotes a profibrotic pathway involving hepatocyte TAZ upregulation.Semantic proximity Read

Thiol methyltransferase METTL7B coordinates lipid metabolism and promotes tumor progression in pancreatic cancerSemantic proximity Read

The structure, catalytic mechanism, and inhibitor identification of phosphatidylinositol remodeling MBOAT7Semantic proximity Read

Association of the Liver and Plasma Lipidomes with the Histological Stage of Alcohol-Related Liver DiseaseSemantic proximity Read