Loss of hepatic Mboat7 leads to liver fibrosis.

doi:10.1136/gutjnl-2020-320853

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Article

Loss of hepatic Mboat7 leads to liver fibrosis.

Gut - 1 May 2021

Thangapandi Veera Raghavan, Knittelfelder Oskar, Brosch Mario, Patsenker Eleonora, Vvedenskaya Olga, Buch Stephan, Hinz Sebastian, Hendricks Alexander, Nati Marina, Herrmann Alexander, Rekhade Devavrat Ravindra, Berg Thomas, Matz-Soja Madlen, Huse Klaus, Klipp Edda, Pauling Josch K, Wodke Judith Ah, Miranda Ackerman Jacobo, Bonin Malte von, Aigner Elmar, Datz Christian, von Schönfels Witigo, Nehring Sophie, Zeissig Sebastian, Röcken Christoph, Dahl Andreas, Chavakis Triantafyllos, Stickel Felix, Shevchenko Andrej, Schafmayer Clemens, Hampe Jochen, Subramanian Pallavi

Abstract excerpt

OBJECTIVE: The rs641738C>T variant located near the membrane-bound O-acyltransferase domain containing 7 (MBOAT7) locus is associated with fibrosis in liver diseases, including non-alcoholic fatty liver disease (NAFLD), alcohol-related liver disease, hepatitis B and C. We aim to understand the mechanism by which the rs641738C>T variant contributes to pathogenesis of NAFLD. DESIGN: Mice with hepatocyte-specific...

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Identifiers

PMID: 32591434
DOI: 10.1136/gutjnl-2020-320853
PMCID: PMC8040158

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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