Article

Urine-derived induced pluripotent stem cells from Klinefelter Syndrome patients exhibit compromised capacity to differentiate into human primordial germ cell-like cells

2026-04-03

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Klinefelter syndrome (KS) represents the most prevalent sex chromosome aneuploidy associated with male infertility. However, the underlying pathogenic mechanisms remain largely unexplored, primarily due to the lack of appropriate disease-relevant cell models and the inaccessibility of early primordial germ cell (PGC) development in vivo. This study aimed to g...

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Literature Corpus work: f991aa0d-ccc3-506a-aba5-2b3e4e447766
DOI: 10.21203/rs.3.rs-9164952/v1

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