Targeting conserved sequences circumvents the evolution of resistance in a viral gene drive against human cytomegalovirus

Abstract excerpt

Gene drives are genetic systems designed to efficiently spread a modification through a population. They have been designed almost exclusively in eukaryotic species, and especially in insects. We recently developed a CRISPR-based gene drive system in herpesviruses that relies on similar mechanisms and could efficiently spread into a population of wildtype viruses. A common consequence of gene drives in insects is...

Topics

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• Alleles
• CRISPR and Genetic Engineering
• CRISPR-Cas Systems
• Cytomegalovirus and herpesvirus research
• Gene Editing
• Genetics, Population
• Herpesvirus Infections and Treatments
• RNA, Guide, CRISPR-Cas Systems

Identifiers and source

Literature Corpus work

eba80b07-609b-59d2-acac-a3ba76f8f7b3

DOI

10.1101/2021.01.08.425902