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Article

Viral gene drive in herpesviruses

28 Sept 2020

Abstract excerpt

Gene drives are genetic modifications designed to propagate in a population with high efficiency. Current gene drive strategies rely on sexual reproduction and are thought to be restricted to sexual organisms. Here, we report on a gene drive system that allows the spread of an engineered trait in populations of DNA viruses and, in particular, herpesviruses. We describe the successful transmission of a gene drive...

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PMID: 32985507
DOI: 10.1038/s41467-020-18678-0

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