Article

Histone H3K27 methyltransferase EZH2 interacts with MEG3-lncRNA to directly regulate integrin signaling and endothelial cell function

2022-05-20

Abstract excerpt

<h4>Summary</h4> Enhancer of Zeste Homologue 2 (EZH2) modulates gene transcription during endothelial cell (EC) dysfunction, via interaction with non-coding RNAs (ncRNAs). Thus, EZH2 can act as a rheostat in deposition of histone H3K27 trimethylation (H3K27me3) to repress many genes. We profiled EZH2-RNA interactions using f ormaldehyde/UV assisted cross-linking l igation a nd s equencing of h ybrids (FLASH-...

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Literature Corpus work: eba65b50-ad35-5dd6-8e7a-eba3c75f49f1
DOI: 10.1101/2022.05.20.492787

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