Article
Gestational diabetes mellitus impairs fetal endothelial cell functions through a mechanism involving microRNA-101 and histone methyltransferase enhancer of zester homolog-2.
Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2015
Floris Ilaria, Descamps Betty, Vardeu Antonella, Mitić Tijana, Posadino Anna Maria, Shantikumar Saran, Sala-Newby Graciela, Capobianco Gianpiero, Mangialardi Giuseppe, Howard Lynsey, Dessole Salvatore, Urrutia Raul, Pintus Gianfranco, Emanueli Costanza
Abstract excerpt
OBJECTIVE: Gestational diabetes mellitus (GDM) produces fetal hyperglycemia with increased lifelong risks for the exposed offspring of cardiovascular and other diseases. Epigenetic mechanisms induce long-term gene expression changes in response to in utero environmental perturbations. Moreover, microRNAs (miRs) control the function of endothelial cells (ECs) under physiological and pathological conditions and can...
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