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EZH2 as an Epigenetic Regulator of Cardiovascular Development and Diseases

24 May 2021

Abstract excerpt

ABSTRACT: Enhancer of zeste homolog 2(EZH2) is an enzymatic subunit of polycomb repressive complex 2 (PRC2) and is responsible for catalyzing mono-, di-, and trimethylation of histone H3 at lysine-27(H3K27me1/2/3). Many noncoding RNAs or signaling pathways are involved in EZH2 functional alterations. This new epigenetic regulation of target genes is able to silence downstream gene expression and modify...

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PMID: 34029268
DOI: 10.1097/fjc.0000000000001062

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