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Evaluating the nonlinear effects of sleep duration on biological aging across phenotypic, genomic, and epigenomic data.

Aging - 25 Aug 2025

Wu Xueyao, Zhao Xunying, Ge Aaron, Han Zhitong, Hou Can, Hao Yu, Xiao Jinyu, Fan Mengyu, Burgess Stephen, Li Jiayuan, Jiang Xia

Abstract excerpt

Short and long sleep durations have been inconsistently linked to aging and health outcomes, potentially due to underexplored nonlinear associations. Using phenotypic and genomic data from the UK Biobank (n=442,664), we applied multivariable linear regression, restricted cubic splines, and Mendelian randomization (MR) to analyze nonlinear relationships between self-reported sleep duration and biomarkers of...

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PMID: 40856643
DOI: 10.18632/aging.206306
PMCID: PMC12422793

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