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Article

Identifying Potential Causal Effects of Telomere Length on Health Outcomes: A Phenome-Wide Investigation and Mendelian Randomization Study.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Jan 2024

Wang Wenxiu, Huang Ninghao, Zhuang Zhenhuang, Song Zimin, Li Yueying, Dong Xue, Xiao Wendi, Zhao Yimin, Jia Jinzhu, Liu Zhonghua, Qi Lu, Huang Tao

Abstract excerpt

BACKGROUND: Telomere length has been linked to various health outcomes. To comprehensively investigate the causal effects of telomere length throughout the human disease spectrum, we conducted a phenome-wide Mendelian randomization study (MR-PheWAS) and a systematic review of MR studies. METHODS: We conducted a PheWAS to screen for associations between telomere length and 1 035 phenotypes in the UK Biobank (n =...

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PMID: 37209418
DOI: 10.1093/gerona/glad128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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