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Article

ATM inhibition enhances the efficacy of radiation across distinct molecular subgroups of pediatric high-grade glioma

27 Mar 2023

Abstract excerpt

BACKGROUND: Pediatric high-grade glioma (pHGG) is largely incurable and accounts for most brain tumor-related deaths in children. Radiation is a standard therapy, yet the benefit from this treatment modality is transient, and most children succumb to disease within 2 years. Recent large-scale genomic studies suggest that pHGG has alterations in DNA damage response (DDR) pathways that induce resistance to DNA...

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PMID: 36971093
DOI: 10.1093/neuonc/noad064

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