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Article

Corticosterone drives behavioral inflexibility via plasticity-related gene expression in the dorsal striatum

2025-07-24

Abstract excerpt

Behavioral flexibility allows organisms to modify actions based on new information, such as shifts in reward value or availability, and is promoted by the dorsomedial striatum (DMS). In contrast, behavioral inflexibility provides efficiency and automaticity in familiar contexts, and is promoted by the dorsolateral striatum (DLS). Importantly, chronic elevation of the primary stress hormone, corticosterone (CORT) i...

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Literature Corpus work
eb99426f-633d-54a7-a49c-86ebbf3278d5
DOI
10.1101/2025.07.24.666631
Open publication

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Corticosterone drives behavioral inflexibility via plasticity-related gene expression in the dorsal striatumDOI 10.1101/2025.07.24.666631
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