CD38+HLA-DR+CD8+ T Cells induced by IL-15 exert liver injury through NKG2D in chronic hepatitis B cirrhosis

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Liver cirrhosis could lead to immune dysfunction. During the pathogenesis of liver cirrhosis, CD8⁺ T cells play a critical role. While CD38⁺HLA-DR⁺CD8⁺ T cells, also called bystander activation CD8⁺ T cells, had been shown to be involved in host injury, its specific contribution to liver cirrhosis had remain...

Topics

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• Ascites
• CD8-Positive T-Lymphocytes
• Disease Susceptibility
• Hepatitis Viruses Studies and Epidemiology
• HLA-DR Antigens
• Immune Cell Function and Interaction
• Liver Cirrhosis
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

3dc85269-1684-5d6e-8264-6f8fde30a2ae

DOI

10.21203/rs.3.rs-3648252/v1