Article

Enhanced IL-15-mediated NK cell activation and proliferation by an ADAM17 function-blocking antibody involves CD16A, CD137, and accessory cells

2024-05-14

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> NK cells are being extensively studied as a cell therapy for cancer. Their effector functions are induced by the recognition of ligands on tumor cells and by various cytokines. IL-15 is broadly used to stimulate endogenous and adoptively transferred NK cells in cancer patients. These stimuli activate the membrane protease ADAM17, which then cleaves assorted receptors on the...

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Literature Corpus work: 7ce01e97-f08b-5647-841b-4e0c8287a1d5
DOI: 10.1101/2024.05.09.593347

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