Article

Abnormalities in core AD biomarkers precede inflammatory and glial markers in CSF in Autosomal Dominant Alzheimer’s Disease

2026-04-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Increasing evidence suggests that accurate prediction of Alzheimer’s disease (AD) symptom onset requires more than amyloid- and tau-centric biomarkers such as cerebrospinal fluid (CSF) Aβ42/40, total tau and p-tau181 and plasma p-tau217. Autosomal dominant AD (ADAD), caused by pathogenic PSEN1, PSEN2 and APP mutations with predictable age at symptom onset, presents a uniqu...

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Literature Corpus work: eb800571-d1e0-54f3-92fd-d513f235da4b
DOI: 10.64898/2026.03.31.26349851

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