Article
Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease.
Science translational medicine - 5 Mar 2014
Fagan Anne M, Xiong Chengjie, Jasielec Mateusz S, Bateman Randall J, Goate Alison M, Benzinger Tammie L S, Ghetti Bernardino, Martins Ralph N, Masters Colin L, Mayeux Richard, Ringman John M, Rossor Martin N, Salloway Stephen, Schofield Peter R, Sperling Reisa A, Marcus Daniel, Cairns Nigel J, Buckles Virginia D, Ladenson Jack H, Morris John C, Holtzman David M
Abstract excerpt
Clinicopathological evidence suggests that the pathology of Alzheimer's disease (AD) begins many years before the appearance of cognitive symptoms. Biomarkers are required to identify affected individuals during this asymptomatic ("preclinical") stage to permit intervention with potential disease-modifying therapies designed to preserve normal brain function. Studies of families with autosomal-dominant AD (ADAD)...
Topics
- Adult
- Alleles
- Alzheimer Disease
- Amyloid beta-Peptides
- Biomarkers
- Cognition
- Cohort Studies
- Cross-Sectional Studies
- Disease Progression