Article
Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease.
Nature medicine - 1 Aug 2023
Johnson Erik C B, Bian Shijia, Haque Rafi U, Carter E Kathleen, Watson Caroline M, Gordon Brian A, Ping Lingyan, Duong Duc M, Epstein Michael P, McDade Eric, Barthélemy Nicolas R, Karch Celeste M, Xiong Chengjie, Cruchaga Carlos, Perrin Richard J, Wingo Aliza P, Wingo Thomas S, Chhatwal Jasmeer P, Day Gregory S, Noble James M, Berman Sarah B, Martins Ralph, Graff-Radford Neill R, Schofield Peter R, Ikeuchi Takeshi, Mori Hiroshi, Levin Johannes, Farlow Martin, Lah James J, Haass Christian, Jucker Mathias, Morris John C, Benzinger Tammie L S, Roberts Blaine R, Bateman Randall J, Fagan Anne M, Seyfried Nicholas T, Levey Allan I
Abstract excerpt
Alzheimer's disease (AD) pathology develops many years before the onset of cognitive symptoms. Two pathological processes-aggregation of the amyloid-β (Aβ) peptide into plaques and the microtubule protein tau into neurofibrillary tangles (NFTs)-are hallmarks of the disease. However, other pathological brain processes are thought to be key disease mediators of Aβ plaque and NFT pathology. How these additional...
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