Article

Systematic proteomics in Autosomal dominant Alzheimer’s disease reveals decades-early changes of CSF proteins in neuronal death, and immune pathways

2024-01-13

Abstract excerpt

<h4>Background</h4> To date, there is no high throughput proteomic study in the context of Autosomal Dominant Alzheimer’s disease (ADAD). Here, we aimed to characterize early CSF proteome changes in ADAD and leverage them as potential biomarkers for disease monitoring and therapeutic strategies. <h4>Methods</h4> We utilized Somascan® 7K assay to quantify protein levels in the CSF from 291 mutation carriers (MCs) a...

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Literature Corpus work: a77a31c7-2ac6-5035-b989-0fe344609609
DOI: 10.1101/2024.01.12.24301242

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