Article
CSF proteomics identifies early changes in autosomal dominant Alzheimer's disease.
Cell - 31 Oct 2024
Shen Yuanyuan, Timsina Jigyasha, Heo Gyujin, Beric Aleksandra, Ali Muhammad, Wang Ciyang, Yang Chengran, Wang Yueyao, Western Daniel, Liu Menghan, Gorijala Priyanka, Budde John, Do Anh, Liu Haiyan, Gordon Brian, Llibre-Guerra Jorge J, Joseph-Mathurin Nelly, Perrin Richard J, Maschi Dario, Wyss-Coray Tony, Pastor Pau, Renton Alan E, Surace Ezequiel I, Johnson Erik C B, Levey Allan I, Alvarez Ignacio, Levin Johannes, Ringman John M, Allegri Ricardo Francisco, Seyfried Nicholas, Day Gregg S, Wu Qisi, Fernández M Victoria, Tarawneh Rawan, McDade Eric, Morris John C, Bateman Randall J, Goate Alison, Ibanez Laura, Sung Yun Ju, Cruchaga Carlos
Abstract excerpt
In this high-throughput proteomic study of autosomal dominant Alzheimer's disease (ADAD), we sought to identify early biomarkers in cerebrospinal fluid (CSF) for disease monitoring and treatment strategies. We examined CSF proteins in 286 mutation carriers (MCs) and 177 non-carriers (NCs). The developed multi-layer regression model distinguished proteins with different pseudo-trajectories between these groups. We...
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