Article

Exploring Disordered Regions of Human Spliceosome Proteins

2026-01-08

Abstract excerpt

Introns are removed from messenger RNAs by the spliceosome, a protein-RNA machinery enriched with intrinsically disordered regions (IDRs). Lacking stable 3D structures, IDRs can adopt diverse conformations interlacing proteins and RNAs components of the spliceosome and regulating splicing. Here we performed a comprehensive bioinformatics analysis of the human spliceosome proteome revealing that many proteins conta...

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Literature Corpus work: c4753204-5818-5084-8aa4-426e3005de82
DOI: 10.64898/2026.01.07.698225

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