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CD276 (B7-H3) as a Companion Diagnostic Biomarker for Glioblastoma: Multi-Platform Validation and Therapeutic Implications

2026-01-08

Abstract excerpt

Glioblastoma (GBM) remains the most lethal primary brain tumor, with median survival of 14-16 months despite aggressive multimodal therapy [1,2] . The failure of PD-1/PD-L1 checkpoint inhibitors in GBM (CheckMate-143) [3] has highlighted the need for alternative immunotherapeutic targets and companion diagnostics. CD276 (B7-H3) has emerged as a promising target, with multiple anti-B7-H3 therapies in clinical dev...

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Literature Corpus work
3d78f56e-0750-548f-a19d-746e3ebe1525
DOI
10.64898/2026.01.07.698199
Open publication

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