Article

Improve the Efficacy of B7-H3-Targeting Antibody-Drug Conjugate DS-7300a in TP53-deficient Tumors by Inducing Ferroptosis

2026-05-08

Abstract excerpt

<h4>ABSTRACT</h4> Immune checkpoint B7-H3 is an emerging target for immunotherapy. DS-7300a is an advanced B7-H3-targeting antibody-drug conjugate (ADC) warheaded with the topoisomerase I inhibitor DXd. DS-7300a has demonstrated clinical activity, but molecular biomarkers to predict its therapeutic response remain elusive. TP53 is one of the most mutated tumor suppressor genes across cancers, and effective thera...

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Literature Corpus work: c694b68e-3c09-54fc-b16a-e086f74d7b54
DOI: 10.64898/2026.05.05.722958

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