Article

Tbx1 haploinsufficiency causes brain metabolic and behavioral anomalies in adult mice which are corrected by vitamin B12 treatment

2024-02-01

Abstract excerpt

<h4>Introduction</h4> The brain-related phenotypes observed in 22q11.2 deletion syndrome (22q11.2DS) are highly variable and their origin is poorly understood. Changes in brain metabolism may cause or contribute to the phenotypes, given that many of the deleted genes (approx. 10%) are implicated in metabolic processes, but this is currently unknown. It is clearly important to address this knowledge gap, but in hu...

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Literature Corpus work: eb4418c0-fd3f-5637-a87b-7ad447951fec
DOI: 10.1101/2024.02.01.578212

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