Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mbnl1 and Mbnl2 regulate brain structural integrity in mice.

Communications biology - 30 Nov 2021

Sta Maria Naomi S, Zhou Chenyu, Lee Se Jung, Valiulahi Parvin, Li Xiandu, Choi Jongkyu, Liu Xiaodan, Jacobs Russell, Comai Lucio, Reddy Sita

Abstract excerpt

Myotonic Dystrophy Type I (DM1) patients demonstrate widespread and variable brain structural alterations whose etiology is unclear. We demonstrate that inactivation of the Muscleblind-like proteins, Mbnl1 and Mbnl2, initiates brain structural defects. 2D FSE T2w MRIs on 4-month-old Mbnl1+/-/Mbnl2-/- mice demonstrate whole-brain volume reductions, ventriculomegaly and regional gray and white matter volume...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotype

Share to RNA-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 34848815
DOI: 10.1038/s42003-021-02845-0
PMCID: PMC8633067

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mbnl1 and Mbnl2 regulate brain structural integrity in mice.PMID 34848815Read ↗

Reduced cytoplasmic MBNL1 is an early event in a brain-specific mouse model of myotonic dystrophySemantic proximity Read ↗

Tbx1, a gene encoded in 22q11.2 copy number variant, is a link between alterations in fimbria myelination and cognitive speed in miceSemantic proximity Read ↗

Transcriptional Signatures of Synaptic Vesicle Genes Define Myotonic Dystrophy Type I NeurodegenerationSemantic proximity Read ↗

Longitudinal MEMRI analysis of brain phenotypes in a mouse model of Niemann-Pick Type C disease.Semantic proximity Read ↗

A MYT1L syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation.Semantic proximity Read ↗

Brain Dysfunction in LAMA2-Related Congenital Muscular Dystrophy: Lessons From Human Case Reports and Mouse ModelsSemantic proximity Read ↗

<i>Tbx1</i> , a 22q11.2-encoded gene, is a link between alterations in fimbria myelination and cognitive speed in miceSemantic proximity Read ↗

A MYT1L Syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturationSemantic proximity Read ↗

Impaired Complex I dysregulates neural/glial precursors and corpus callosum development revealing postnatal defects in Leigh Syndrome miceSemantic proximity Read ↗

Compound loss of muscleblind‐like function in myotonic dystrophySemantic proximity Read ↗

The neuroanatomy of Eml1 knockout mice, a model of subcortical heterotopiaSemantic proximity Read ↗

Tbx1 haploinsufficiency causes brain metabolic and behavioral anomalies in adult mice which are corrected by vitamin B12 treatmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.