Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Etiology and treatment of adrenoleukodystrophy: new insights from Drosophila.

Disease models & mechanisms - 15 Jun 2018

Gordon Hannah B, Valdez Lourdes, Letsou Anthea

Abstract excerpt

Adrenoleukodystrophy (ALD) is a fatal progressive neurodegenerative disorder affecting brain white matter. The most common form of ALD is X-linked (X-ALD) and results from mutation of the ABCD1-encoded very-long-chain fatty acid (VLCFA) transporter. X-ALD is clinically heterogeneous, with the cerebral form being the most severe. Diagnosed in boys usually between the ages of 4 and 8 years, cerebral X-ALD symptoms...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenoleukodystrophy
Share to Central Nervous System
Share to Drosophila melanogaster

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Fatty Acids

Share to Gene-Environment Interaction

Share to Nerve Degeneration

Share to Penetrance

Source

Open in PubMed Open full text

Identifiers

PMID: 29739804
DOI: 10.1242/dmm.031286
PMCID: PMC6031365

Genes

ABCD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Etiology and treatment of adrenoleukodystrophy: new insights from Drosophila.PMID 29739804Read ↗

Neurodegeneration in a Drosophila model of adrenoleukodystrophy: the roles of the Bubblegum and Double bubble acyl-CoA synthetases.Semantic proximity Read ↗

Genetic analysis of the X-linked adrenoleukodystrophy gene ABCD1 in Drosophila uncovers a conserved phenotype.Semantic proximity Read ↗

Management of adrenoleukodystrophy: From pre-clinical studies to the development of new therapies.Semantic proximity Read ↗

Management of adrenoleukodystrophy: From pre-clinical studies to the development of new therapiesSemantic proximity Read ↗

Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy.Semantic proximity Read ↗

Adrenoleukodystrophy: Current understanding of disease mechanisms, diagnosis, and therapeutic advances-a recent review.Semantic proximity Read ↗

ABCD1 and X-linked adrenoleukodystrophy: A disease with a markedly variable phenotype showing conserved neurobiology in animal models.Semantic proximity Read ↗

Genetic analysis of the X-linked Adrenoleukodystrophy <i>ABCD1 gene</i> in <i>Drosophila</i> uncovers a role in Peroxisomal dynamicsSemantic proximity Read ↗

Evolution of adrenoleukodystrophy model systems.Semantic proximity Read ↗

Elovl1 inhibition reduced very long chain fatty acids in a mouse model of adrenoleukodystrophySemantic proximity Read ↗

X-linked adrenoleukodystrophy: pathogenesis and treatment.Semantic proximity Read ↗

From gene to therapy: a review of deciphering the role of ABCD1 in combating X-Linked adrenoleukodystrophy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.