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Metabolomic Fingerprint of Mecp2-Deficient Mouse Cortex: Evidence for a Pronounced Multi-Facetted Metabolic Component in Rett Syndrome.

Cells - 21 Sept 2021

Golubiani Gocha, Lagani Vincenzo, Solomonia Revaz, Müller Michael

Abstract excerpt

Using unsupervised metabolomics, we defined the complex metabolic conditions in the cortex of a mouse model of Rett syndrome (RTT). RTT, which represents a cause of mental and cognitive disabilities in females, results in profound cognitive impairment with autistic features, motor disabilities, seizures, gastrointestinal problems, and cardiorespiratory irregularities. Typical RTT originates from mutations in the...

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Identifiers

PMID: 34572143
DOI: 10.3390/cells10092494
PMCID: PMC8472238

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