Article

Altered Hepatic Metabolism in Down Syndrome

2025-05-31

Abstract excerpt

<h4>ABSTRACT</h4> Trisomy 21 (T21) gives rise to Down syndrome (DS), the most commonly occurring chromosomal abnormality in humans. T21 affects nearly every organ and tissue system in the body, predisposing individuals with DS to congenital heart defects, autoimmunity, and Alzheimer’s disease, among other co-occurring conditions. Here, using multi-omic analysis of plasma from more than 400 people, we report broad...

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Literature Corpus work: 6828cc6a-1fe1-518c-8082-856a6d6c099e
DOI: 10.1101/2025.05.27.656393

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