Article

Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures

2017-05-04

Abstract excerpt

We read with great interest the paper by Williams, et. al. [1], who argued for neutral evolution in tumors by analyzing The Cancer Genome Atlas (TCGA) data. They supported this conclusion by showing high R 2 values for fits to a neutral evolution model predicting M ∝ 1 / f , where M is the number of somatic mutations with allele frequency ≥ f . However, we believe a conclusion of neutrality must be treated c...

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Literature Corpus work: eb3de0cd-63b0-537f-8fb8-ada686d98045
DOI: 10.1101/134049

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