Article
A pan-cancer signature of neutral tumor evolution
2015-02-11
Abstract excerpt
Despite extraordinary efforts to profile cancer genomes on a large scale, interpreting the vast amount of genomic data in the light of cancer evolution and in a clinically relevant manner remains challenging. Here we demonstrate that cancer next-generation sequencing data is dominated by the signature of growth governed by a power-law distribution of mutant allele frequencies. The power-law signature is common to...
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Identifiers and source
- Literature Corpus work
- 083acc98-40c4-5e77-b2e0-1e058ff3f059
- DOI
- 10.1101/014894