Article
Clinical and genomic characterization of neutral tumor evolution in Head and Neck Squamous Cell Carcinoma.
Genomics - 1 Sept 2020
Li Rui, Dong Jingsi, Zhang Hongwan, Zhao Qi, Li Xingyang, Liu Xuefei, Ye Ying, Deng Shuang, Lin Dongxin, Zheng Jian, Zuo Zhixiang
Abstract excerpt
Recent studies suggest that a significant proportion of cancers undergo neutral tumor evolution. We applied neutral evolution model in HNSCC patients from The Cancer Genome Atlas (TCGA). To ensure the accuracy of classification results, a sample with the purity of tumor <0.7 was excluded. A tumor sample was considered to evolve neutrally if R2 ≥ 0.98. We found that about 16% of HNSCC patients undergo neutral...
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