Article
Tumorigenesis as the Paradigm of Quasi-neutral Molecular Evolution.
Molecular biology and evolution - 1 Jul 2019
Chen Bingjie, Shi Zongkun, Chen Qingjian, Shen Xu, Shibata Darryl, Wen Haijun, Wu Chung-I
Abstract excerpt
In the absence of both positive and negative selections, coding sequences evolve at a neutral rate (R = 1). Such a high genomic rate is generally not achievable due to the prevalence of negative selection against codon substitutions. Remarkably, somatic evolution exhibits the seemingly neutral rate R ∼ 1 across normal and cancerous tissues. Nevertheless, R ∼ 1 may also mean that positive and negative selections...
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