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Unfolding of viral protein 1 N-termini facilitates genome ejection from recombinant adeno-associated virus serotype 8

24 Apr 2025

Abstract excerpt

The role of viral protein (VP) 1 and VP2, which comprise the recombinant adeno-associated virus (rAAV) capsid, in heat-induced genome release was investigated using rAAV serotype 8 (rAAV8) samples with a high VP1/VP2 to VP3 ratio, a low VP1/VP2 to VP3 ratio, and VP3 only. The thermal unfolding of the VP1 N-termini was closely monitored by nano-differential scanning fluorimetry with an onset temperature ( T onset1...

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PMID: 40469751
DOI: 10.1016/j.omtm.2025.101480

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