Article

Curing genetic skin disease through altered replication stress response

2020-08-20

Abstract excerpt

<h4>Summary</h4> Revertant mosaicism, or ‘natural gene therapy’, refers to the spontaneous in vivo reversion of an inherited mutation in a somatic cell 1 . Only ∼50 human genetic disorders exhibit revertant mosaicism, implicating a distinctive role played by mutant proteins in somatic correction of a pathogenic germline mutation 2 . However, the process by which mutant proteins induce somatic genetic reversion...

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Literature Corpus work: 9092edbb-ae78-5cda-8577-c26d795fcccb
DOI: 10.1101/2020.08.19.255430

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