Article

Regulatory networks driving expression of genes critical for glioblastoma are controlled by the transcription factor c-Jun and the pre-existing epigenetic modifications

2022-07-19

Abstract excerpt

<h4>Background</h4> Glioblastoma (GBM, WHO grade IV) is an aggressive, primary brain tumor. Despite gross surgery and forceful radio- and chemotherapy, survival of GBM patients did not improve over decades. Several studies reported transcription deregulation in GBMs but regulatory mechanisms driving overexpression of GBM-specific genes remain largely unknown. Transcription in open chromatin regions is directed by...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8a916acb-f3e6-5194-b951-a76bb4881b86
DOI: 10.1101/2022.07.18.500476

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Regulatory networks driving expression of genes critical for glioblastoma are controlled by the transcription factor c-Jun and the pre-existing epigenetic modificationsDOI 10.1101/2022.07.18.500476Read

Regulatory networks driving expression of genes critical for glioblastoma are controlled by the transcription factor c-Jun and the pre-existing epigenetic modificationsSemantic proximity Read

Mapping chromatin accessibility and active regulatory elements reveals new pathological mechanisms in human gliomasSemantic proximity Read

Identification of Key Differentially Expressed Transcription Factors in GlioblastomaSemantic proximity Read

Integration of Multi-omics Data Revealed the Orphan CpG Islands and Enhancer-dominated Cis-regulatory Network in GliomaSemantic proximity Read

c-Jun-N-terminal phosphorylation regulates DNMT1 expression and genome wide methylation in gliomasSemantic proximity Read

A Novel Prognostic Signature of Transcription Factors for the Prediction in Patients With GBMSemantic proximity Read

Identification of new targets for glioblastoma therapy based on a DNA expression microarraySemantic proximity Read

Forkhead box transcription factors (FOXOs and FOXM1) in glioma: from molecular mechanisms to therapeuticsSemantic proximity Read

Epigenetic regulation of differentially expressed genes between various glioma typesSemantic proximity Read

Positive feedback loop of c-myc/XTP6/NDH2/NF-κB to promote malignant progression in glioblastomaSemantic proximity Read

Unveiling the Diagnostic and Prognostic potential of BMP Pathway and Hypoxia-inducible Factors in Glioblastoma MultiformeSemantic proximity Read

Transcription factors in glioblastoma – Molecular pathogenesis and clinical implicationsSemantic proximity Read