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Integration of Multi-omics Data Revealed the Orphan CpG Islands and Enhancer-dominated Cis-regulatory Network in Glioma

2024-02-19

Abstract excerpt

<h4>Background: </h4> The complex transcriptional regulatory network leads to the poor prognosis of glioma. The role of orphan CpG islands (oCGIs) in the transcriptional regulatory network has been overlooked. Establishing a sophisticated transcriptional regulatory system is paramount. <h4>Methods: </h4>: We constructed different cis-regulatory models through mutual information and Bayesian networks. We utilized e...

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Literature Corpus work
7155d5aa-2dbb-520f-b4f4-c82a840fa999
DOI
10.21203/rs.3.rs-3959082/v1
Open publication

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Integration of Multi-omics Data Revealed the Orphan CpG Islands and Enhancer-dominated Cis-regulatory Network in GliomaDOI 10.21203/rs.3.rs-3959082/v1
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