Article

A pH-sensitive switch activates virulence in <i>Salmonella</i>

2022-12-16

Abstract excerpt

<h4>ABSTRACT</h4> The transcriptional regulator SsrB acts as a switch between virulent and biofilm lifestyles of non-typhoidal Salmonella enterica serovar Typhimurium. During infection, phosphorylated SsrB activates genes on Salmonella Pathogenicity Island-2 (SPI-2) essential for survival and replication within the macrophage. Low pH inside the vacuole is a key inducer of expression and SsrB activation. Previou...

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Literature Corpus work: eaf6b791-8ae0-5c5f-abae-84153488f651
DOI: 10.1101/2022.12.15.520350

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