Article

Phosphate sensing by PhoPR regulates the cytotoxicity of <i>Staphylococcus aureus</i>

2025-06-24

Abstract excerpt

Staphylococcus aureus has evolved a complex regulatory network to coordinate expression of virulence factors, including cytolytic toxins, with host environmental signals. Central to this network are two-component systems, in which a histidine kinase senses an external signal and activates a response regulator via phosphorylation, leading to changes in gene expression. Using a comprehensive screen of transposon mut...

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Literature Corpus work: 7015dd52-c4c5-5c45-b846-3b1c70b9853c
DOI: 10.1101/2025.06.24.661297

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