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AdiY Acts as a Cytoplasmic pH-Sensor via Histidine Protonation to Regulate Acid Stress Adaptation in <i>Escherichia coli</i>

2025-10-05

Abstract excerpt

The arginine-dependent acid resistance (Adi) system is a vital component that enables Escherichia coli and other enterobacteria to withstand the extreme acidity in the human gastrointestinal tract. It consists of the proton-consuming decarboxylation of arginine, catalyzed by AdiA, and the uptake of arginine, as well as the excretion of the more alkaline agmatine, catalyzed by the antiporter AdiC. The correspondin...

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Literature Corpus work
28807ce9-1ded-5df0-a877-fbe4b7831a6d
DOI
10.1101/2025.10.03.680266
Open publication

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