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A Roadmap for Human Liver Differentiation from Pluripotent Stem Cells

1 Feb 2018

Abstract excerpt

How are closely related lineages, including liver, pancreas, and intestines, diversified from a common endodermal origin? Here, we apply principles learned from developmental biology to rapidly reconstitute liver progenitors from human pluripotent stem cells (hPSCs). Mapping the formation of multiple endodermal lineages revealed how alternate endodermal fates (e.g., pancreas and intestines) are restricted during...

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PMID: 29466743
DOI: 10.1016/j.celrep.2018.01.087

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