Human iPSC-Derived Posterior Gut Progenitors Are Expandable and Capable of Forming Gut and Liver Organoids

Abstract excerpt

Early endoderm progenitors naturally possess robust propagating potential to develop a majority of meter-long gastrointestinal tracts and are therefore considered as a promising source for therapy. Here, we demonstrated the reproducible generation of human CDX2 + posterior gut endoderm cells (PGECs) from five induced pluripotent stem cell clones by manipulating FGF , TGF , and WNT signaling. Transcriptome...

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