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Article

Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells.

PloS one - 11 Aug 2010

Roelandt Philip, Pauwelyn Karen Ann, Sancho-Bru Pau, Subramanian Kartik, Bose Bipasha, Ordovas Laura, Vanuytsel Kim, Geraerts Martine, Firpo Meri, De Vos Rita, Fevery Johan, Nevens Frederik, Hu Wei-Shou, Verfaillie Catherine M

Abstract excerpt

Stem cell-derived hepatocytes may be an alternative cell source to treat liver diseases or to be used for pharmacological purposes. We developed a protocol that mimics mammalian liver development, to differentiate cells with pluripotent characteristics to hepatocyte-like cells. The protocol suppo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20711405
DOI: 10.1371/journal.pone.0012101
PMCID: PMC2920330

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20711405-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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