Article
Prolonged chronic social defeat stress promotes less resilience and higher uniformity in depression-like behaviors in adult male mice.
Biochemical and biophysical research communications - 14 May 2021
Lu Jian, Gong Xue, Yao Xiao, Guang Yu, Yang Hongjiang, Ji Runan, He Yong, Zhou Wei, Wang Haiyang, Wang Wei, Bai Shunjie, Guo Hua, Guo Zengcai V, Xie Peng
Abstract excerpt
Chronic social defeat stress (CSDS) is widely applied to study of depression in rodents. 10-day CSDS was a most commonly employed paradigm but with high resilience ratio (∼30%), producing potential variation in depression-like behavioral symptoms. Whether prolonged period (21 days) of CSDS would promote less resilience and reduce behavioral variability remains unknown. We applied 10-day and 21-day CSDS paradigms...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.