Article

Stress vulnerability promotes an alcohol prone phenotype in a preclinical model of sustained depression

2018-06-29

Abstract excerpt

Major depression and alcohol-related disorders frequently co-occur. Depression severity weighs on the magnitude and persistence of comorbid alcohol use disorder (AUD), with severe implications for disease prognosis. Here, we investigated whether depression vulnerability drives propensity to AUD at the preclinical level. We used the social defeat-induced persistent stress (SDPS) model of chronic depression in combi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 227ca91b-e42b-517e-b1e9-5b302d530514
DOI: 10.1101/358606

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Stress vulnerability promotes an alcohol prone phenotype in a preclinical model of sustained depressionDOI 10.1101/358606Read

Bidirectional relationship between alcohol intake and sensitivity to social defeat: association with Tacr1 and Avp expression.Semantic proximity Read

Prolonged chronic social defeat stress promotes less resilience and higher uniformity in depression-like behaviors in adult male mice.Semantic proximity Read

Towards a machine-learning assisted diagnosis of psychiatric disorders and their operationalization in preclinical research: evidence from studies on addiction-like behaviour in individual ratsSemantic proximity Read

Sex-Dependent Cross-Resilience to Social Defeat and Learned Helplessness: The Role of BDNF-ERK Signaling and NorepinephrineSemantic proximity Read

Large-scale characterization of cocaine addiction-like behaviors reveals that escalation of intake, aversion-resistant responding, and breaking-points are highly correlated measures of the same constructSemantic proximity Read

The Wistar Kyoto Rat: A Model of Depression Traits.Semantic proximity Read

High susceptibility to chronic social stress is associated with a depression-like phenotype.Semantic proximity Read

A multi-symptomatic model of heroin use disorder in rats reveals distinct behavioral profiles and neuronal correlates of heroin vulnerability versus resiliencySemantic proximity Read

Novelty-seeking behavior predicts vulnerability in a rodent model of depression.Semantic proximity Read

Stress-induced motivational impairment is marked by diminished frontocortical cellular communication and neuropeptide signalingSemantic proximity Read

Voluntary alcohol intake in two rat lines selectively bred for learned helpless and non-helpless behavior.Semantic proximity Read

Early life stress in male mice blunts responsiveness in a translationally-relevant reward taskSemantic proximity Read