Article
Forced isoform switching of Neat1_1 to Neat1_2 leads to the loss of Neat1_1 and the hyperformation of paraspeckles but does not affect the development and growth of mice.
RNA (New York, N.Y.) - 1 Mar 2020
Isobe Momo, Toya Hikaru, Mito Mari, Chiba Tomoki, Asahara Hiroshi, Hirose Tetsuro, Nakagawa Shinichi
Abstract excerpt
Neat1 is a long noncoding RNA (lncRNA) that serves as an architectural component of the nuclear bodies known as paraspeckles. Two isoforms of Neat1, the short isoform Neat1_1 and the long isoform Neat1_2, are generated from the same gene locus by alternative 3' processing. Neat1_1 is the most abundant and the best conserved isoform expressed in various cell types, whereas Neat1_2 is expressed in a small...
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